Veja os estudos científicos realizados para o Ácido Hialurônico HAPLEX Plus:

1). Nutraceuticals World, 2016.

2). Fraser JR, Laurent TC, Laurent UB. Hyaluronan: its nature, distribution, functions and turnover. J Intern Med. 1997; 242:27–33.

3). Laurent TC, Fraser JR. Hyaluronan. FASEB J. 1992; 6: 2397–402.

4). J. R. E. FRASER , T. C. LAURENT, U. B. G. LAURENT. Hyaluronan: its nature, distribution, functions and turnover Journal of Internal Medicine 1997; 242: 27–33.

5). Atlas of Osteoarthritis. Springer. 2015. p. 21. ISBN 9781910315163.

6). Bagga H, Burkhardt D, Sambrook P, March L. Longterm effects of intraarticular hyaluronan on synovial fluid in osteoarthritis of the knee. J Rheumatol. 2006; 33: 946–50.

7). Shimizu C, Kubo T, Hirasawa Y, Coutts RD, Amiel D. Histomorphometric and biochemical effect of various hyaluronans on early osteoarthritis. J Rheumatol. 1998; 25: 1813–9.

8). Listrat V, Ayral X, Patarnello F, Bonvarlet JP, Simonnet J, Amor B, et al. Arthroscopic evaluation of potential structure modifying activity of hyaluronan (Hyalgan) in osteoarthritis of the knee. Osteoarthritis Cartilage. 1997; 5: 153–60.

9). Ghosh P, Holbert C, Read R, Armstrong S. Hyaluronic acid (hyaluronan) in experimental osteoarthritis. J Rheumatol Suppl. 1995; 43: 155–7.

10). Wenz W, Breusch SJ, Graf J, Stratmann U. Ultrastructural findings after intraarticular application of hyaluronan in a canine model of arthropathy. J Orthop Res. 2000; 18: 604–12.

11). Frizziero L, Govoni E, Bacchini P. Intra-articular hyaluronic acid in the treatment of osteoarthritis of the knee: clinical and morphological study. Clin ExpRheumatol. 1998; 16: 441–9.

12). Guidolin DD, Ronchetti IP, Lini E, Guerra D, Frizziero L. Morphological analysis of articular cartilage biopsies from a randomized, clinical study comparing the effects of 500–730 kDa sodium hyaluronate (Hyalgan) and methylprednisolone acetate on primary osteoarthritis of the knee. Osteoarthritis Cartilage. 2001; 9: 371–81.

13). Maniwa S, Ochi M, Motomura T, Nishikori T, Chen J, Naora H. Effects of hyaluronic acid and basic fibroblast growth factor on motility of chondrocytes and synovial cells in culture. Acta Orthop Scand. 2001; 72: 299–303.

14). Asari A, Miyauchi S, Matsuzaka S, Ito T, Kominami E, Uchiyama Y. Molecular eight-dependent effects of hyaluronate on the arthritic synovium. Arch Histol Cytol. 1998; 61: 125–35.

15). Day R, Brooks P, Conaghan PG, Petersen M. A double blind, randomized, multicenter, parallel group study of the effectiveness and tolerance of intraarticular hyaluronan in osteoarthritis of the knee. J Rheumatol. 2004; 31: 775–82.

16). Reed RK, Lilja K, Laurent TC. Hyaluronan in the rat with special reference to the skin. Acta Physiol Scand. 1988; 134: 405-411.

17). Laurent UB, Dahl LB, Reed RK. Catabolism of hyaluronan in rabbit skin takes place locally, in lumph nodes and liver. Exp Physio. 1991; 76: 695-703.

18). Reed RK, Lilja K, Laurent TC: Acta Hyaluronan in the rat with specialreference to the skin. Physiol Scand. 1988, 134(3):405–411.

19). Bucci LR, Turpin AA: Will the real hyaluronan please stand up? J Appl Nutr. 2004, 54:10–33.

Veja os estudos científicos realizados para o Colágeno Verisol:

1) JOURNAL OF MEDICINAL FOOD, J Med Food 00 (0) 2015, 1–9, DOI: 10.1089/jmf.2015.0022, Dietary Supplementation with Specific Collagen Peptides Has a Body Mass Index-Dependent Beneficial Effect on Cellulite Morphology, Michael Schunck, 1 Vivian Zague, 2 Steffen Oesser, 1 Ehrhardt Proksch, 3

2) Proksch, E., et al. Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: A double-blind, placebo-controlled study. Skin Pharmacology and Physiology, v. 27, n.1, p. 47–55, 2013.

3) Oesser S, Adam M, Babel W, Seifert J: Oral administration of (14)C labeled gelatin hydrolysate leads to an accumulation of radioactivity in cartilage of mice (C57/BL).
J Nutr 1999;129:1891 – 1895.

4) Watanabe-Kamiyama M, Shimizu M, Kamiyama S, Taguchi Y, Sone H, Morimatsu F, Shirakawa H, Furukawa Y, Komai M: Absorption and effectiveness of orally administered low molecular weight collagen hydrolysate in rats. J Agric Food Chem 27-1-2010;58:835 – 841.

5) Rawlings AV, Harding CR: Moisturization and skin barrier function. Dermatol Ther 2004;17 Suppl 1:43 – 48.

6) Sandilands A, Sutherland C, Irvine AD, McLean WH: Filaggrin in the frontline: role in skin barrier function and disease. J Cell Sci 1-5-2009;122:1285 – 1294.

7) Primavera G, Berardesca E: Clinical and instrumental evaluation of a food supplement in improving skin hydration. Int J Cosmet Sci 2005;27:199 – 204.

8) Shin JE, Oh JH, Kim YK, Jung JY, Chung JH: Transcriptional regulation of proteoglycans and glycosaminoglycan chain-synthesizing glycosyltransferases by UV irradiation in cultured human dermal fibroblasts. J Korean Med Sci 2011;26:417 – 424.

9)Reinboth B, Hanssen E, Cleary EG, Gibson MA: Molecular interactions of biglycan and decorin with elastic fiber components: biglycan forms a ternary complex with tropoelastin and microfibril-associated glycoprotein 1. J Biol Chem 8-2-2002;277:3950 – 3957.

10)Proksch E, Segger D, Degwert J, Schunck M, Zague V, Oesser S: Oral Supplementation of Specific Collagen Peptides has Beneficial Effects on Human Skin Physiology: A Double-Blind, Placebo-Controlled Study. Skin Pharmacol Physiol 2014;27:47 – 55.

11) Proksch E, Schunck M, Zague V, Segger D, Degwert J, Oesser S: Oral Intake of Specic
Bioactive Collagen Peptides Reduces Skin Wrinkles and Increases Dermal Matrix Synthesis.
Skin Pharmacol Physiol 2014;27:113-119